对 31例原发性肝癌 (PHC)、 32例肝硬化患者及 2 0例正常人进行了血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)的活性测定 ,对 31例 PHC患者治疗前后 GPDA的含量进行了对比分析 ,并与甲胎蛋白 (AFP)的诊断价值进行对比。结果显示 ,GPDA对 PHC的诊断敏感性为 74.2 % ,优于 AFP诊断敏感性 6 7.7% ,特别是在 AFP阴性的 PHC患者中 ,GPDA的阳性率高达 6 0 % ,弥补了 AFP对 PHC诊断阳性率低的不足 Serum glycyl-proline dipeptidyl aminopeptidase (GPDA) activity was measured in 31 patients with primary liver cancer (PHC), 32 patients with cirrhosis, and 20 normal subjects. Before and after treatment in 31 patients with PHC The content of GPDA was compared and compared with the diagnostic value of alpha-fetoprotein (AFP). The results showed that the diagnostic sensitivity of GPDA for PHC was 74.2%, which was better than the sensitivity of AFP diagnosis (6.77%). Especially for patients with AFP negative PHC, the positive rate of GPDA was as high as 60%, which made up for AFP positive diagnosis of PHC. Insufficient rate