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本文对 30 0名早期自然流产患者的 314例 (14名两次流产 )绒毛标本的染色体进行分析 ,检出异常核型 130例 ,检出率 41 40 % ,涉及的异常染色体有 1、2、3、4、6、7、8、9、10、11、13、14、15、16、18、2 0、2 1、2 2、X、Y。异常类型有 :常染色体三体、双重三体、性染色体三体、性染色体单体、三倍体、四倍体、嵌合体、常染色体结构异常等。并对流产儿染色体异常的再现风险及流产次数和流产儿性别与染色体异常的关系以及流产儿染色体结构异常与双亲染色体相关性等问题进行了讨论。结果表明 :流产儿染色体异常是导致早期自然流产的主要原因之一 ,开展自然流产儿染色体的研究 ,对自然流产的病因、诊断与再孕及选择合理的治疗有重要的临床指导意义。
In this paper, the chromosomal analysis of 314 cases (14 abortion) villi from 30 cases of early spontaneous abortion was analyzed. 130 cases of abnormal karyotype were detected, the detection rate was 41 40%, the abnormal chromosomes involved were 1, 2, 3,4,6,7,8,9,10,11,13,14,15,16,18,2 0,2 1,2 2, X, Y. Abnormal types are: autosomal trisomy, double trisomy, sex chromosome trisomy, sex chromosome monomer, triploid, tetraploid, chimeric, autosomal structural abnormalities. The risk of reproductive chromosomal abnormalities and the number of abortions and the relationship between genital and chromosomal abnormalities in abortion and the relationship between chromosomal structural abnormalities and chromosomes in parents were also discussed. The results showed that chromosomal abnormalities in abortion were one of the main causes of early spontaneous abortion. To study the chromosomes of spontaneous abortion has important clinical significance for the etiology, diagnosis and pregnancy of spontaneous abortion and the rational treatment.