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目的观察甲氨蝶呤预防持续性异位妊娠的临床效果。方法随机选取我院2014年—2015年因异位妊娠要求行保守手术的患者80例,平均分为观察组与治疗组各40例。2组均行输卵管切开取胚术,治疗组术中同时于输卵管病灶系膜处注射甲氨蝶呤,观察组不给予任何药物治疗。观察2组术后持续性异位妊娠的发病率。结果治疗组预防持续性异位妊娠有效率97.5%,明显高于观察组的77.5%,差异具有明显统计学意义(P<0.05)。结论术中同时于输卵管病灶系膜处注射甲氨蝶呤能显著减少持续性异位妊娠发病率,是一种简单、安全、有效的方法。
Objective To observe the clinical efficacy of methotrexate in the prevention of persistent ectopic pregnancy. Methods Totally 80 patients who underwent conservative operation requiring ectopic pregnancy in our hospital from 2014 to 2015 were randomly divided into observation group and treatment group with 40 cases in each group. Both groups underwent tubal excision and embryo implantation. Methotrexate was injected into the mesorectum of the tubal lesion simultaneously in the treatment group while no treatment was given in the observation group. The incidence of persistent ectopic pregnancy was observed in two groups. Results The effective rate of prevention of persistent ectopic pregnancy in the treatment group was 97.5%, which was significantly higher than that in the observation group (77.5%), the difference was statistically significant (P <0.05). Conclusions Simultaneous intraoperative injection of methotrexate in the mesangial tubal lesion can significantly reduce the incidence of persistent ectopic pregnancy, which is a simple, safe and effective method.