论文部分内容阅读
[目的]分析鼻咽癌调强放疗对海马结构相关的认知功能的影响。[方法]利用韦氏成人记忆力量表中的敏感项目对51例鼻咽癌放疗后1年患者(分为T1~2组和T3~4组)行记忆力相关的神经认知功能检测,同时比较相匹配的鼻咽癌放疗前患者和健康人各30例的各项记忆力检测结果差异。[结果]记忆力相关的神经认知功能检测显示:放疗后T1~2期组和T3~4期组除“数字广度—逆向”无显著差异外,其余各项均有统计学意义,T3~4组患者的认知功能明显低于T1~2期组;鼻咽癌放疗前患者和健康人在联想学习、数字累加、数字广度、视觉再生方面检测结果差异无统计学意义。[结论]鼻咽癌调强放疗可导致海马结构功能相关的认知功能损害,特别在T3~4期放疗病例中值得关注。
[Objective] To analyze the effect of intensity modulated radiotherapy of nasopharyngeal carcinoma on the cognitive function of hippocampal formation. [Methods] With the sensitive items in Wechsler Adult Memory Scale, we evaluated the memory-related neurocognitive function of 51 patients with T1N2 cancer and T3 ~ 4 one year after radiotherapy. At the same time, Differences in memory test results between 30 matched NPC patients and healthy individuals before radiotherapy. [Results] Memory-related neurocognitive tests showed that there was no significant difference except for “digital breadth-reverse” in T1 ~ 2 and T3 ~ The cognitive function of ~ 4 groups was significantly lower than that of T1 ~ 2 group. There was no significant difference in the results of association learning, numerical accumulation, digital breadth and visual regeneration before radiotherapy for patients with nasopharyngeal carcinoma. [Conclusion] IMRT can lead to impaired cognitive function of the hippocampus, especially in cases of radiotherapy of stage T3 ~ 4.