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本实验采用同时测定血清磷脂酶Ａ２（ＰＬＡ２）和脂质过氧化代谢终产物丙二醛（ＭＤＡ）的方法，动态观察两者在犬肠缺血性休克中的作用及促甲状腺素释放激素（ＴＲＨ）对它们的影响。结果显示：休克后，血清ＰＬＡ＿２活性和血清ＭＤＡ含量均明显升高，与平均动脉压呈显著负相关。而两者间则存在显著正相关关系，两者协同参与了肠缺血性休克的发生发展过程。静脉注射ＴＲＨ能有效地抑制血清ＰＬＡ。活性升高和明显地降低血清ＭＤＡ含量，这可能是ＴＲＨ抗休克机理的一个重要因素。
In this study, simultaneous determination of serum phospholipase A2 (PLA2) and lipid peroxidation metabolizing end product malondialdehyde (MDA) method to dynamically observe the role of the two in canine ischemic shock and thyrotropin-releasing hormone TRH) on them. The results showed that after shock, serum PLA 2 activity and serum MDA levels were significantly increased, and negatively correlated with mean arterial pressure. However, there was a significant positive correlation between the two, which synergistically involved in the development of intestinal ischemia shock. Intravenous TRH can effectively inhibit serum PLA. Activity and significantly reduce serum MDA levels, which may be TRH anti-shock mechanism is an important factor.