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目的 :观察使用地高辛患者的疗效。方法 :测地高辛血药浓度和观察患者症状。结果 :抽查 92 4例采用地高辛治疗的各类心脏病患者 ,其中没有达到疗效的有 10 5例 ,发生率为 11.4 % ,中毒者 88例 ,发生率为 9.5 % ,中毒者平均年龄为 64岁 ,中毒发生时间在服药后 2 0d。中毒者的血药浓度为 ( 2 .9± 0 .5 ) μg·L-1。结论 :统计分析显示 ,当地高辛浓度小于 0 .8μg·L-1时无效 ,大于 2 .0 μg·L-1时如出现中毒症状 ,应及早调整剂量和采取必要补救措施。
Objective: To observe the effect of using digoxin in patients. Methods: digoxin plasma concentration and observe the symptoms of patients. Results: A total of 92 4 patients with various types of heart disease treated with digoxin were enrolled in this study. Among them, 105 did not achieve efficacy, the incidence rate was 11.4%, 88 cases were poisoned, the incidence rate was 9.5%. The average age of poisoning was 64 years old, poisoning time after taking medication 20d. The concentration of poisoning poisoning was (2.9 ± 0.5) μg · L-1. Conclusion: The statistical analysis shows that when the local concentration of digoxin is less than 0.8 μg · L-1, if the symptom of poisoning is more than 2.0 μg · L-1, the dosage should be adjusted as soon as possible and the necessary remedial measures should be taken.