本实验观察了Ｔ－２毒素对大鼠心肌损伤的超微结构改变及硒的保护作用。结果表明，Ｔ—２毒素亚急性中毒大鼠心肌损伤十分明显，部分心肌纤维走向紊乱、扭曲，可见散在性出血灶。超微结构的变化主要表现在心肌肌膜、肌浆网、肌原纤维以及线粒体的变化。肌原纤维走向紊乱，Ｚ线增粗，肌原纤维成片状消失，肌膜增厚，肌膜外胶原原纤维增生，线粒体出现空泡变性。硒对Ｔ─２毒素致心肌损伤超微结构变化与克山病的基本型变化相似，提示在研究克山病的病因时，应当考虑镰刀菌毒素所起的作用。 This experiment observed the T-2 toxin on myocardial ultrastructure changes and selenium protective effect. The results showed that T-2 toxin sub-acute poisoning rats with myocardial injury is very obvious, some of the myocardial fibers to disorder, distorted, visible scattered hemorrhage. Changes in ultrastructure mainly in the myocardium, sarcoplasmic reticulum, myofibrils and mitochondrial changes. Myofibrillar to disorder, Z line thickening, myofibrils disappear into a sheet, sarcopenia, extramembranous collagen fibrillation, mitochondria vacuolar degeneration. The ultrastructural changes of myocardium induced by T-2 toxin were similar to those of Keshan disease, suggesting that the role of Fusarium toxins should be considered in the study of the etiology of Keshan disease.