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通过检测低密度脂蛋白受体相关蛋白5(LRP-5)在不同分化程度胃癌中的表达差异及其与胃癌患者临床病理资料之间的关系,探讨LRP-5在胃癌发病过程中的作用.采用实时荧光定量PCR及免疫组化的方法,对比分析了26例高分化、35例中分化、48例低分化胃癌及15例正常胃组织中LRP-5基因在转录和翻译水平的表达情况.实时荧光定量PCR和免疫组化结果均显示:LRP-5在中分化胃癌、低分化胃癌组织中的表达量高于正常胃组织,差异有统计学意义(P<0.05),在高分化胃癌组织中与正常胃组织之间比较无明显差别(P>0.05).结合临床资料分析表明,LRP-5蛋白在伴有淋巴结转移的胃癌组织中表达高于淋巴结未转移胃癌组织(P<0.05),与胃癌患者年龄、性别因素无关.提示LRP-5与胃癌的发生、发展、转移和恶性程度相关,可作为胃癌的诊断、分级和预后的判断依据.
To investigate the role of LRP-5 in the pathogenesis of gastric cancer by detecting the expression of low density lipoprotein receptor-related protein 5 (LRP-5) in differentiated gastric cancer and its clinicopathological data. The expression of LRP-5 gene in 26 cases of well differentiated, 35 cases of moderately differentiated, 48 cases of poorly differentiated gastric cancer and 15 cases of normal gastric tissues was analyzed by real-time fluorescence quantitative PCR and immunohistochemistry. The results of real-time fluorescence quantitative PCR and immunohistochemistry showed that the expression of LRP-5 in moderately differentiated gastric cancer and poorly differentiated gastric cancer tissues was higher than that in normal gastric tissues (P <0.05). In well differentiated gastric cancer tissues (P> 0.05) .According to the clinical data, the expression of LRP-5 protein in gastric cancer tissues with lymph node metastasis was significantly higher than that in non-metastatic gastric cancer tissues (P <0.05) Which is not related to the age and sex of gastric cancer patients.It is suggested that LRP-5 is related to the occurrence, development, metastasis and malignancy of gastric cancer and can be used as the basis for the diagnosis, classification and prognosis of gastric cancer.