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在正常细胞周期中,肿瘤抑制基因产物p53和细胞周期素D1有协同作用。如果这种协同作用异常就可导致细胞的恶变。许多人类癌瘤中已确定突变型p53蛋白的过度表达。为探讨周期素D1在子宫内膜癌发生中的作用,对58例正常子宫内膜和74例子宫内膜癌进行研究。据FIGO分期和分级,其中Ⅰ期51例,Ⅱ期8例,Ⅲ期15例,内有G1 39例,G2 23例,G3 12例。所有标本均用10％磷酸盐缓冲的
In the normal cell cycle, the tumor suppressor gene p53 and cyclin D1 have a synergistic effect. If this synergistic abnormalities can lead to malignant cells. Overexpression of mutant p53 protein has been identified in many human carcinomas. To investigate the role of cyclin D1 in the pathogenesis of endometrial carcinoma, 58 normal endometrium and 74 endometrial carcinoma were studied. According to FIGO staging and grading, there were 51 cases in stage Ⅰ, 8 cases in stage Ⅱ and 15 cases in stage Ⅲ, there were 39 cases in G1, 23 cases in G2 and 12 cases in G3. All specimens were buffered with 10% phosphate