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a-干扰素(IFN-α)短程疗法能降低丁型肝炎病人血清转氨酶和丁型肝炎病毒(HDV)RNA,但维持疗效短。本文报告IFN-α长程(12个月)治疗HDV感染的结果。作者选择慢性HDV感染患者11例。病例选择标准为:HBsAg和总HDV抗体持续阳性6个月以上;病理检查示慢性活动性肝炎或进展期肝硬化;肝细胞内HDV抗原阳性;1年内未使用免疫调节剂,半年内无注射
A-interferon (IFN-α) short-course therapy can reduce serum transaminase and hepatitis D virus (HDV) RNA in patients with hepatitis D, but maintain a short course of treatment. This article reports the results of long-term (12 months) treatment of HDV infection with IFN-α. The authors selected 11 patients with chronic HDV infection. Case selection criteria: HBsAg and total HDV antibodies continued to be positive for more than 6 months; pathological examination showed chronic active hepatitis or advanced cirrhosis; hepatocytes positive for HDV antigen; 1 year without the use of immunomodulatory agents within six months without injection