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按照现代药理学观点,亚甲蓝(MC)解救各种家畜的亚硝酸盐中毒,均用其小剂量(1—2mg/kg),而解救氰化物中毒则用其大剂量(10mg/kg)。然而,作者在实验教学和诊疗过程中发现,家兔的亚硝酸盐中毒,用小剂量MC静脉注射解毒,几乎无一例救活。为提高实验效果和治疗效果,减少经济损失,特设计了MC用量的筛选实验,现将结果报导如下。
According to modern pharmacology, methylene blue (MC) rescues nitrite poisoning in various domestic animals with low doses (1–2 mg/kg), while high doses (10 mg/kg) are used for rescue of cyanide poisoning. . However, during the experiment teaching and diagnosis, the authors found that rabbits suffered from nitrite poisoning and detoxification with a small dose of intravenous MC. There was almost no survival. In order to improve the experimental and therapeutic effects and reduce economic losses, a screening experiment for MC dosage has been specially designed. The results are reported below.