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目的:探讨青年乳腺癌中ER、CerbB-2、XIAP、Smac表达情况的临床特征及其意义。方法:应用免疫组化SP法检测32例青年乳腺癌的ER、CerbB-2、XIAP、Smac的表达情况,与同期住院年龄≥40岁的乳腺癌中随机抽取44例相比较。结果:32例青年乳腺癌中ER、CerbB-2、XIAP、Smac阳性表达率分别是43.8%(14/32)、62.5%(20/32)、78.1%(25/32)、34.4%(11/32)。中老年乳腺癌ER、CerbB-2、XIAP、Smac阳性表达率分别是72.7%(32/44)、31.8%(14/44)、54.5%(24/44)、61.4%(27/44)。青年乳腺癌的ER、Smac表达低于中老年乳腺癌,CerbB-2、XIAP表达高于中老年乳腺癌。结论:青年乳腺癌侵袭性强,恶性程度高,预后差。这不但与ER、CerbB-2的表达不同有关,青年乳腺癌的细胞调亡受到抑制也是重要原因之一,应对青年乳腺癌患者充分重视。
Objective: To investigate the clinical features and significance of ER, CerbB-2, XIAP and Smac expression in young breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of ER, CerbB-2, XIAP, and Smac in 32 cases of young breast cancer, compared with 44 cases randomly selected from hospitalized patients with breast cancer≥40 years old. Results: The positive rates of ER, CerbB-2, XIAP and Smac in 32 cases of young breast cancer were 43.8% (14/32), 62.5% (20/32), 78.1% (25/32), and 34.4% (11 /32). The positive rates of ER, CerbB-2, XIAP and Smac in breast cancer were 72.7% (32/44), 31.8% (14/44), 54.5% (24/44), and 61.4% (27/44) respectively. The expression of ER and Smac in young breast cancer patients was lower than that in middle-aged and old patients. The expression of CerbB-2 and XIAP was higher than that in middle-aged and old patients. Conclusions: Young breast cancer has strong invasiveness, high degree of malignancy and poor prognosis. This is not only related to the different expression of ER and CerbB-2. The inhibition of cell apoptosis in young breast cancer is also one of the important reasons. The young breast cancer patients should be given full attention.