作者对1984年美国俄亥俄州东北部发生的26例遗传性溶血性贫血患者的流行性纯红细胞再生障碍性贫血(下简称再障)作了调查。男14、女12例,年龄2～23岁。其中镰状细胞病20例,血红蛋白 SC 病4例,镰状细胞-β地中海贫血和遗传性球形细胞增多症各1例。这些病人在纯红细胞再障出现前1～17(中位数4)天都已有前驱症状:发热、畏寒、嗜睡或疲乏;85%有 The authors investigated the prevalence of pure red cell aplasia in 26 hereditary hemolytic anemias in northeastern Ohio in 1984. Male 14, female 12 cases, aged 2 to 23 years old. Among them, there were 20 cases of sickle cell disease, 4 cases of hemoglobin SC disease, 1 case of sickle cell-β thalassemia and hereditary spherocytosis. These patients had prodromal symptoms 1 to 17 (median 4) days prior to the appearance of pure red cell aplasia: fever, chills, lethargy, or fatigue; 85% had