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目的 :观察雌激素受体 (ER)、孕激素受体 (PR)和 p53、C- erb B- 2、nm2 3基因在乳腺癌组织中的表达并探讨其临床意义。方法 :应用免疫组化 S- P法 ,对 96例乳腺癌组织进行了 ER、PR、p53、C- erb B- 2、nm2 3检测 ,结合临床表现及随访结果作统计学分析。结果 :ER、PR、p53、C- erb B- 2、nm2 3阳性表达率分别为 52 .1 %、47.9%、46.9%、62 .5%、70 .8%。浸润型乳腺癌组织 C- erb B- 2阳性表达明显高于非浸润型(P<0 .0 1 ) ;ER、PR、p53、nm2 3阳性表达与病理类型无关 (P>0 .0 5)。有淋巴结转移组 p53、C- erb B- 2的阳性表达率明显高于无淋巴结转移组 ,有淋巴结转移组 nm2 3的阳性表达率显著低于无淋巴结转移组 ,差异均有非常显著性 (P<0 .0 1 ) ;而 ER、PR的阳性表达率与淋巴结转移与否无关 (P>0 .0 5)。 ER和 (或 ) PR、nm2 3阳性组乳腺癌复发率明显低于阴性组 (P<0 .0 5) ,而 p53、C- erb B- 2阳性组乳腺癌复发率明显高于阴性组 (P<0 .0 5)。结论 :检测乳腺癌组织中的 ER、PR及 p53、C- erb B- 2、nm2 3基因对评价乳腺癌患者的预后有重要价值。
Objective: To observe the expression of estrogen receptor (ER), progesterone receptor (PR) and p53, C-erb B-2 and nm23 genes in breast cancer and to investigate its clinical significance. Methods: The expressions of ER, PR, p53, C-erb B-2 and nm23 in 96 cases of breast cancer were detected by immunohistochemical S-P method. The clinical manifestations and follow-up results were analyzed statistically. Results: The positive rates of ER, PR, p53, C-erb B-2 and nm23 were 52.1%, 47.9%, 46.9%, 62.5% and 70.8% respectively. The positive expression of C-erb B-2 in infiltrative breast cancer was significantly higher than that in non-infiltrative breast (P <0.01). The positive expression of ER, PR, p53 and nm23 was not related to pathological type (P> 0.05) . The positive rate of p53 and C-erb B-2 in lymph node metastasis was significantly higher than that in non-lymph node metastasis, and the positive rate of nm23 in lymph node metastasis was significantly lower than that in non-lymph node metastasis (P <0.01). However, the positive rates of ER and PR were not related to lymph node metastasis (P> 0.05). The recurrence rate of ER and / or PR, nm23 positive group was significantly lower than that of negative group (P <0.05), while the recurrence rate of p53 and C erb B-2 positive group was significantly higher than that of negative group P <0. 05). Conclusion: The detection of ER, PR, p53, C-erb B-2 and nm23 genes in breast cancer tissue is of great value in evaluating the prognosis of patients with breast cancer.