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目的:通过对目标时间内药物不良反应(adverse drug reactions,ADR)人群的分析,识别高风险用药人群,并给予相应指导。方法:将中日友好医院2009年1月至2014年1月门诊患者发生ADR进行数据收集并整理分析,通过风险矩阵与Borda序值法相结合,分辨特征人群风险概率和风险程度。结果:男性发生ADR风险略高于女性;部分人群发生ADR时与抗菌药物联用存在相关性;特殊群体用药存高风险且合并其他影响因素。结论:正确识别临床用药高风险人群,对日常药品安全管理具有重要意义,根据患者情况给予适当用药咨询,可减少ADR发生,并改善患者预后。
OBJECTIVE: To identify high-risk drug users by analyzing the population of adverse drug reactions (ADR) within the target time and to provide appropriate guidance. Methods: The ADR data of outpatients from January 2009 to January 2014 in Sino-Japan Friendship Hospital were collected and analyzed. The risk matrix and Borda ordinal value method were combined to distinguish the risk probability and risk degree of the characteristic population. Results: The risk of ADR in men was slightly higher than that in women. There was a correlation between ADR and some antibiotics in some people. Other groups were associated with high risk and other factors. Conclusions: Correctly identifying the high-risk population of clinical medication is of great significance to the routine drug safety management. According to the patient’s condition, proper medication counseling can reduce the occurrence of ADR and improve the prognosis of patients.