论文部分内容阅读
目的了解深圳市2009年手足口病病原学情况,为制定手足口病防控策略及实现手足口病对症治疗提供科学依据。方法采集2009年491例手足口病病例的粪便标本,应用荧光逆转录聚合酶链反应(RT-PCR)方法,检测肠道病毒71型(enterovirus 71,EV71)和柯萨奇病毒A 16型(coxsackievirus A16,CA16)RNA。结果 EV71阳性率为30.96%,CA16阳性率为19.14%;EV71和CA16的阳性率差异有统计学意义;不同性别之间EV71和CA16阳性率差异无统计学意义。其中59例重症及死亡病例中,EV71阳性率为54.24%,CA16阳性率为1.69%。重症及死亡病例集中在3~10月份,1、2月份和11、12月份未发现重症及死亡病例;7例手足口病死亡病例中,5例EV71阳性。结论 2009年深圳市手足口病病原体主要为EV71;3~7月份为手足口病高发季节,要特别加强对EV71引起的有中枢神经系统并发症的重症病例的监测,提前做好抢救措施,防止病情恶化导致死亡。
Objective To understand the etiopathogenisis of hand-foot-mouth disease in Shenzhen in 2009 and provide a scientific basis for the prevention and control of hand-foot-mouth disease and the symptomatic treatment of hand-foot-mouth disease. Methods A total of 491 cases of HFMD in 2009 were collected for stool specimens. The stool samples of enterovirus 71 (EV71) and coxsackievirus A 16 (RT-PCR) coxsackievirus A16, CA16) RNA. Results The positive rate of EV71 was 30.96%, the positive rate of CA16 was 19.14%. There was significant difference between the positive rates of EV71 and CA16. There was no significant difference in the positive rates of EV71 and CA16 between different sexes. Among 59 cases of severe cases and deaths, the positive rate of EV71 was 54.24% and the positive rate of CA16 was 1.69%. Severe and fatal cases were concentrated between March and October. No severe or fatal cases were found in January and February and in November and December. Among the seven cases of HFMD, 5 were EV71 positive. Conclusion The main pathogens of hand-foot-mouth disease in Shenzhen in 2009 are EV71. From March to July, the incidence of hand-foot-mouth disease is especially high. Special attention should be paid to the monitoring of severe cases of central nervous system complications caused by EV71. Illness leads to death.