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目的探讨Ⅰ期胎盘部位滋养细胞肿瘤(placental site trophoblastic tumor,PSTT)的临床特点及影响预后的相关因素。方法对2001-2014年首都医科大学附属北京妇产医院诊疗的6例Ⅰ期PSTT患者病例资料进行回顾性分析。结果 6例患者年龄24~38岁,平均28.8岁;1例距前次妊娠时间>2年;1例最高血β-HCG>10 000 m IU/ml;2例患者接受保留生育功能的手术治疗,未复发;5年生存率为83%;Ⅰ期PSTT影响预后的因素包括年龄>35岁,发病间隔前次妊娠时间>2年,血β-HCG水平>10 000 m IU/ml。结论患者年龄、最高血β-HCG、距前次妊娠间隔时间与不良预后相关。若无上述高危因素且病灶局限,有强烈生育要求的患者可保留生育功能。
Objective To investigate the clinical features and prognostic factors of stage Ⅰ placental site trophoblastic tumor (PSTT). Methods Six patients with stage Ⅰ PSTT diagnosed and treated in Beijing Maternity Hospital affiliated to Capital Medical University from 2001 to 2014 were retrospectively analyzed. Results Six patients were aged 24 to 38 years with an average of 28.8 years old. One patient had a history of> 2 years from the previous pregnancy, and one patient had the highest serum level of HCG> 10,000 mIU / ml. Two patients underwent surgery to preserve fertility , And no recurrence. The 5-year survival rate was 83%. The factors that affected the prognosis of stage Ⅰ PSTT included age> 35 years, the interval of the previous pregnancy> 2 years and the blood serum HCG> 10,000 mU / ml. Conclusion The patient’s age, the highest blood β-HCG, is related to the poor prognosis of the previous pregnancy interval. Without the above-mentioned risk factors and focal lesions, patients with strong fertility requirements may retain fertility.