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TRPC3/6通道在心肌缺血再灌注损伤过程中的作用及其机制研究廖燕宏(华中科技大学同济医学院解剖学系,湖北武汉430030)心肌缺血再灌注损伤(MIRI)是指心脏在缺血基础上恢复血流后损伤反而加重,甚至发生不可逆性损伤的现象。减轻再灌注时胞内钙超载对缓解MIRI有至关重要的作用。经典瞬时受体电位(TRPC)通道是位于细胞膜上的一类重要的非选择性阳离子通道,选择性通透钠离子、钙离子。TRPC共有七个亚族成员,根据氨基酸序列的同源性差异,
Role of TRPC3 / 6 channel in myocardial ischemia reperfusion injury and its mechanism LIAO Yan-hong (Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) Myocardial ischemia-reperfusion injury (MIRI) Based on the restoration of blood flow but worse, or even irreversible damage phenomenon. Mitigating intracellular calcium overload during reperfusion is crucial for alleviating MIRI. The classical transient receptor potential (TRPC) channel is an important class of non-selective cation channels located on the cell membrane that selectively permeate sodium ions and calcium ions. TRPC a total of seven members of the Asian family, according to the amino acid sequence homology differences,