抗生素已经成为一种重要的高效药物用于治疗细菌性感染。随着时间推移,抗生素的成功使用也伴随着许多问题产生,如滥用抗生素,具有抗药性细菌的快速传播。氟喹诺酮类抗生素是一类属于氟喹诺酮家族的人工合成具有抗菌活性的药物,已非常广泛地应用于临床和兽类,最主要用于治疗UTI类的疾病。细菌对氟喹诺酮类抗生素抗药性的产生主要通过目标基因突变和增加药物外泵作用的突变实现。 Antibiotics have become an important and highly effective drug for the treatment of bacterial infections. Over time, the successful use of antibiotics is accompanied by many problems, such as the abuse of antibiotics and the rapid spread of drug-resistant bacteria. Fluoroquinolones are a class of artificially synthesized antifungal drugs belonging to the fluoroquinolone family and have been used clinically and in a wide range of mammals and most of them for the treatment of UTIs. Bacteria fluoroquinolone antibiotic resistance mainly through mutations in the target gene and increase drug pump mutations.