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核因子 κB(nuclearfactor κB ,NF κB)是一种多向性核转录调节蛋白 ,参与多种炎症介质基因的转录和调控 ,在炎症、免疫反应中发挥重要作用。近年来研究发现肠粘膜在缺血 /再灌注过程中NF κB活化的分子机制及其与缺血 /再灌注肠粘膜损伤关系的研究进展作一综述
Nuclear factor κB (NF κB) is a multidirectional nuclear transcription regulator that is involved in the transcription and regulation of a variety of inflammatory mediators and plays an important role in inflammation and immune response. In recent years, it has been found that the molecular mechanism of NF κB activation in intestinal mucosa during ischemia / reperfusion and its relationship with ischemia / reperfusion intestinal mucosal injury are reviewed