目的：观察羧甲基茯苓多糖（ＣＭＰ）对人外周血淋巴细胞（ＨＰＢＬ） 产生肿瘤坏死因子（ＴＮＦ） 、白细胞介素６（ＩＬ６）的促诱生作用。方法：用ＨＰＢＬ 经ＣＭＰ预处理作用后再以ＰＨＡ 或和Ｃｏｎ Ａ刺激，培养后测定上清液中ＴＮＦ和ＩＬ６ 活性。结果：ＣＭＰ促诱生组比仅用ＰＨＡ 或／ 和Ｃｏｎ Ａ 常规刺激组培养上清液中的ＴＮＦ效价高０ ．５１ ．０ 倍，ＩＬ６ 效价高０ ．５０ ．８ 倍，ＣＭＰ＋ ＰＨＡ＋ Ｃｏｎ Ａ组对上述两种细胞因子的促诱生作用更加明显。结论：ＣＭＰ是一种有效的细胞因子促诱生剂。 Objective: To observe the pro-induced effects of carboxymethylguanidine (CMP) on the production of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in human peripheral blood lymphocytes (HPBL). Methods: HPBL was pretreated with CMP and then stimulated with PHA and Con A. After culture, supernatants were assayed for TNF and IL-6 activity. RESULTS: In the CMP-promoted group, TNF titers were higher in culture supernatants than those in the conventional stimulation group with PHA alone or with Con A. 5-1. 0 times, IL 6 high titer. 5-0. At 8-fold, the CMP+ PHA+Con A group had more pronounced effects on the induction of these two cytokines. Conclusion: CMP is a potent cytokine-promoting agent.