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目的了解成都市健康成年人群麻疹抗体水平,探讨成人的麻疹疫苗免疫策略,为有效实施麻疹预防和控制策略提供依据。方法 2015年对18岁以上健康成人共2914名采用酶联免疫吸附试验(ELISA)法进行麻疹Ig G抗体浓度检测。结果麻疹抗体阳性率97.12%,保护率44.85%,几何平均浓度(GMC)为710.35 m IU/ml。18~岁、20~岁、30~岁、40~岁年龄段人群的麻疹抗体浓度、抗体阳性率和保护率均相对较低,其中18~岁、20~岁年龄组抗体保护率水平仅为30.43%和34.87%,育龄期妇女麻疹抗体浓度、抗体阳性率和保护率均相对较低;麻疹抗体阳性率、保护率、GMC男性均高于女性、农村地区高于城区和郊区。结论在保证儿童常规免疫高覆盖率的基础上,可根据成人免疫水平适当调整麻疹免疫策略,开展成人麻疹疫苗免疫,重点针对18~40岁人群、育龄妇女为主要接种对象。
Objective To understand the level of measles antibody in healthy adult population in Chengdu and to explore the immunization strategy of adult measles vaccine in order to provide evidence for the effective implementation of measles prevention and control strategies. Methods In 2015, a total of 2914 healthy adults aged 18 years or older were tested for Ig G antibody by enzyme-linked immunosorbent assay (ELISA). Results The positive rate of measles antibody was 97.12%, the protection rate was 44.85%, and the geometric mean concentration (GMC) was 710.35 m IU / ml. The measles antibody concentration, antibody positive rate and protection rate in 18 ~ 20, 30 ~ 40, and 40 ~ age groups were relatively low, of which the antibody protection rate of 18 ~ 20 years old group was only 30.43% and 34.87% respectively. The concentration of measles antibody, antibody positive rate and protection rate in women of childbearing age were relatively low. The positive rate and protective rate of measles antibody were higher in males than in females in rural areas and higher in rural areas than in urban areas and suburbs. Conclusion On the basis of ensuring the high coverage rate of routine immunization in children, measles immunization strategy can be appropriately adjusted according to the level of adult immunity and the immunization against adult measles vaccine can be carried out. The target population of women aged 18-40 years and women of childbearing age are mainly vaccinated.