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目的探讨血管性假性血友病因子(vWF)与妊娠期高血压综合征(PIHS)的相关性。方法用ELISA法测定下列各组患者血清vWF浓度:子痫前期组(A组)患者25例(轻度11例,A1组;重度14例,A2组);妊娠期高血压组(B组)患者15例;正常孕妇晚孕组(C组)15例;另取正常育龄非妊娠妇女15例为对照组(D组)。结果A组vWF浓度为(2.11±0.37)ng/ml,明显高于B组的(1.76±0.30)ng/ml,C组的(1.51±0.56)ng/ml和D组的(0.99±0.25)ng/ml(P<0.05)。A2组vWF浓度为(2.31+0.42)ng/ml,明显高于A1组的(1.85±0.25)ng/ml(P<0.05)。C组vWF浓度明显高于D组(P<0.05)。结论血浆vWF浓度随PIHS和子痫的严重程度而升高,可以作为内皮细胞功能受损的一项指标。
Objective To investigate the relationship between von Willebrand factor (vWF) and gestational hypertension (PIHS). Methods Serum levels of vWF were determined by ELISA in 25 patients with preeclampsia (group A) (mild in 11, group A1; severe in 14, group A2); gestational hypertension (group B) 15 cases of patients; 15 cases of normal pregnant women of late pregnancy group (C group); another 15 cases of non-pregnant women of normal childbearing age as control group (D group). Results The vWF concentration in group A was (2.11 ± 0.37) ng / ml, significantly higher than that in group B (1.76 ± 0.30) ng / ml in group B and (1.51 ± 0.56) ng / ng / ml (P <0.05). The vWF concentration in A2 group was (2.31 + 0.42) ng / ml, significantly higher than that in A1 group (1.85 ± 0.25) ng / ml (P <0.05). The concentration of vWF in group C was significantly higher than that in group D (P <0.05). Conclusions Plasma vWF levels increase with the severity of PIHS and eclampsia and may be used as an indicator of endothelial dysfunction.