阳离子-π作用是一种存在于阳离子和芳香性体系之间的相互作用,与一些经典的作用(如氢键、静电和疏水相互作用)相比,被认为是一种新型分子间作用,普遍存在于生物体系中,对分子识别、蛋白质和核酸的结构与功能起着十分重要的作用.本文结合我们课题组的研究工作,对生物体内存在的典型的阳离子-π作用,以及有关阳离子-π作用的实验与理论计算研究进行综述. The cation-π interaction, an interaction existing between cation and aromatic systems, is considered to be a novel intermolecular interaction with some classical effects (such as hydrogen bonding, electrostatic and hydrophobic interaction) Exists in the biological system and plays an important role in the structure and function of molecular recognition, protein and nucleic acid.In this paper, combining with the research work of our research group, we present the typical cation-π interactions in organisms and the related cation- The role of experimental and theoretical calculations are reviewed.