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目的对亚胺培南-西司他丁所致癫痫进行分析,探讨其影响因素,为临床合理用药提供依据。方法回顾性总结7例亚胺培南-西司他丁致癫痫发作患者,对其进行汇总分析。结果亚胺培南-西司他丁所致癫痫患者7例,原发病以呼吸系统感染为主要因素,癫痫症状发作最早出现于用药后10min,最晚于用药后第14天,患者表现为阵发性全身抽搐,强直性痉挛发作。结论亚胺培南-西司他丁可致癫痫发作,临床需合理用药,应高度重视。
Objective To analyze epilepsy caused by imipenem-cilastatin and explore its influencing factors, so as to provide basis for clinical rational drug use. Methods Retrospective analysis of 7 cases of imipenem-cilastatin-induced epileptic seizures. Results Seven patients with epilepsy were induced by imipenem-cilastatin. The primary disease was respiratory infection. The onset of epileptic symptoms first appeared at 10 min after drug administration and no later than 14 days after drug administration. The patients showed as Paroxysmal generalized convulsions, episodes of tonic spasms. Conclusions Imipenem-cilastatin can cause seizures and should be treated clinically properly.