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目的探讨睾丸精原细胞瘤间质内淋巴细胞存在的实际意义。方法应用单克隆抗体ＣＤ４、ＣＤ８对５４例典型精原细胞瘤间质Ｔ淋巴细胞进行标记，并参照肿瘤的核分裂、坏死、肉芽肿形成及患者的生存期等项指标进行统计学分析。结果ＣＤ４＋、ＣＤ８＋阳性细胞平均数与肿瘤细胞的核分裂数（Ｐ＜００１）、坏死程度（Ｐ＜００１）、肉芽肿形成（Ｐ＜００５）和患者的存活期（Ｐ＜００１）密切相关。结论①ＣＤ４＋、ＣＤ８＋阳性细胞比值大者，肿瘤分化程度高、患者预后好；②对精原细胞瘤间质Ｔ淋巴细胞亚群的检测不仅可判别肿瘤的生物学行为、评估患者的预后，还有望在将来为肿瘤的免疫学治疗开辟新的途径。
Objective To explore the significance of the existence of interstitial lymphocytes in testicular seminoma. Methods Totally 54 cases of typical seminoma stromal T lymphocytes were labeled with monoclonal antibodies CD4 and CD8, and statistical analysis was made according to such indicators as the occurrence of mitosis, necrosis, granuloma formation and patient survival. Results The average number of CD4 + and CD8 + positive cells was significantly correlated with the number of tumor cells (P <001), necrosis (P <001), granuloma formation (P <005) and patient’s survival (P < 0 01) are closely related. Conclusion ①The ratio of CD4 + and CD8 + positive cells is high, the degree of tumor differentiation is high, and the prognosis of patients is good. ②The detection of stromal T lymphocyte subsets in seminoma can not only judge the biological behavior of tumor, but also evaluate the prognosis of patients. In the future for the immunotherapy of tumors to open up new avenues.