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盐诱导激酶1(salt-inducible kinase 1,SIK1)是一种丝氨酸/苏氨酸激酶,属于腺苷酸活化激酶(AMP-activated protein kinase,AMPK)家族[1]。近年发现SIK1不仅调节糖脂代谢,而且参与高血压的发生。SIK1在遗传性高血压大鼠肾小管上皮细胞高表达,通过信号转导通路激活Na+-K+-ATPase,促进钠的吸
Salt-inducible kinase 1 (SIK1) is a serine / threonine kinase belonging to the AMP-activated protein kinase (AMPK) family [1]. SIK1 found in recent years not only regulate glucose and lipid metabolism, but also involved in the occurrence of hypertension. SIK1 is highly expressed in renal tubular epithelial cells of hereditary hypertensive rats and promotes Na + -K + -ATPase through the signal transduction pathway