目的　探讨家兔全脑缺血对小脑皮质蒲肯野细胞的损害。方法　用电镜观察缺血后的超微结构改变。结果随着缺血、缺血再灌时间延长 ,蒲肯野细胞肿胀 ,线粒体嵴部分断裂 ,空泡样变 ,细胞突起间的部分桥粒样结构移位。结论　缺血再灌比单纯缺血对蒲肯野细胞的损害更大。 Objective To investigate the damage of Purkinje cells in the cerebellar cortex of rabbits with global cerebral ischemia. Methods Electron microscopy was used to observe ultrastructural changes after ischemia. Results With the prolongation of ischemia and reperfusion time, Purkinje cell swelling, mitochondrial crista fracture, vacuolar degeneration and part of the desmosome-like structure shift among the cell processes. Conclusion Ischemia-reperfusion injury Purkinje cells more damage than pure ischemia.