2. 您的位置
3. 首页
4. 期刊论文
5. 小胶质细胞在缺血性脑卒中中的双重作用及机制

小胶质细胞在缺血性脑卒中中的双重作用及机制

来源 :生理学报 | 被引量 : 0次 | 上传用户：jianxiangqiao

【摘 要】

：

脑卒中是全球范围内继癌症后导致成年人死亡的第二大病因,同时也是导致成年人伤残的主要原因,其中由大脑缺血引起的缺血性脑卒中占绝大多数.中枢神经系统的小胶质细胞在应对脑缺血损伤反应中发挥神经保护和损伤双重作用:一方面,小胶质细胞参与了脑卒中后神经功能恢复过程,包括促进炎症消退、细胞碎片清除、神经再生和突触重塑等;另一方面,小胶质细胞的过度激活加重神经损伤.本文简述了小胶质细胞在脑卒中后的激活机制,着重探讨了其不同功能对脑卒中后神经损伤和恢复的影响,深入探索脑缺血后小胶质细胞的损伤和保护机制将为脑卒中治疗提供新

【作 者】

：

程明星 李晨辉 孟卫 王琛 

【机 构】

：

中国药科大学生命科学与技术学院,天然药物活性组分与药效国家重点实验室,南京211198;中国药科大学理学院,南京211198

【出 处】

：

生理学报

【发表日期】

：

2021年6期

【关键词】

：

缺血性脑卒中 小胶质细胞 炎症反应 吞噬作用 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

脑卒中是全球范围内继癌症后导致成年人死亡的第二大病因,同时也是导致成年人伤残的主要原因,其中由大脑缺血引起的缺血性脑卒中占绝大多数.中枢神经系统的小胶质细胞在应对脑缺血损伤反应中发挥神经保护和损伤双重作用:一方面,小胶质细胞参与了脑卒中后神经功能恢复过程,包括促进炎症消退、细胞碎片清除、神经再生和突触重塑等;另一方面,小胶质细胞的过度激活加重神经损伤.本文简述了小胶质细胞在脑卒中后的激活机制,着重探讨了其不同功能对脑卒中后神经损伤和恢复的影响,深入探索脑缺血后小胶质细胞的损伤和保护机制将为脑卒中治疗提供新靶点和新策略.

其他文献

细胞原纤毛与人类疾病

细胞原纤毛定位于绝大多数哺乳动物细胞表面,属于非常保守的细胞器,调节细胞增殖、分化、迁移、极性、信号级联等生命活动来调控细胞生命进程和维持细胞稳态.原纤毛结构蛋白或附属蛋白编码基因突变所导致的疾病统称为“纤毛类疾病”,发生在胚胎期、婴儿期甚至成人期.纤毛类疾病不仅累及单一器官,也涉及多器官多系统,表现出多变表型和重叠表型.本文主要综述原纤毛相关基因突变对骨骼、牙齿、皮肤、肝胆、肾脏、大脑、视网膜、心脏等器官的影响,揭示其致病机制,并对当前一些纤毛类疾病新型治疗方法进行探讨.

期刊

细胞原纤毛纤毛类疾病器官治疗

Time history of seismic earth pressure response from gravity retaining wall based on energy dissipat

The seismic design of gravity retaining walls is based mostly on the pseudo static method.The seismic earth pressure is assumed to be a constant without considering the wave traveling effect when the seismic wave propagates through the slope.However,under

期刊

Energy dissipationTime history of seismic earth pressure responseSlip surface

Field investigations and numerical modeling of a giant landslide in the region of Eastern Himalayan

Eastern Himalayan Syntaxis (EHS) is a tectonically active region that undergoes continuous geomorphic changes.Large landslides are predominant in this region.A giant landslide called Jiaobunong landslide on the northwestern flank of the EHS were studied a

期刊

Eastern Himalayan syntaxisAncient landslideFormation mechanismEvolution proce

Spatial modeling of solar photovoltaic power plant in Kabul,Afghanistan

Energy planning and solar plant site selections are vital strategic decisions and one of the most complex executive challenges in the interconnected procedures.It is essential to study the potential renewable energy sources in Afghanistan to select the mo

期刊

PhotovoltaicSpatial modelingAHPANPKabulGIS

Impact of an artificial chute cutoff on the river morphology and flow structure in Sipaikou area of

Artificial chute cutoff can fundamentally eliminate the threat of flood caused by the meandering river,but it significantly changes its morphodynamic characteristics.Channel adjustments after cutoff are rapid,which makes it difficult to study the interact

期刊

Artificial chute cutoffFlow recirculationHydrodynamicScour holeYellow River

Identification of hidden faults using determining velocity structure profile by spatial autocorrelat

Characterizing the subsurface structure is an important parameter for the improvement of seismic hazard assessment.Due to the tectonic complexity of the earth,some deep fractures do not reach the earth\'s surface and are not detectable with visual analy

期刊

Subsurface StructureHidden FaultArray MicrotremorSPAC MethodVs ProfileMashh

A combined survey to evaluate the thermal behavior of loess for a landslide-prone slope on the Heifa

A combined survey including infrared thermography (IRT) and field-laboratory tests were conducted to analyze the thermal responses and thermal properties of loess on a landslide-prone loess slope in the Heifangtai terrace in Northwest China aiming at prel

期刊

Infrared ThermographyLoess landslideThe Heifangtai terraceThermal responseWa

Mechanical behavior of underground pipe gallery structure considering ground fissure

The mechanical behavior of underground pipe gallery is a key research issue due to the static/dynamic states which exist in a ground fissure area.This study took an underground pipe gallery project in Xi\'an,China as the research object.We analyzed the

期刊

Ground fissureUnderground pipe galleryFinite element simulationDynamic respon

Integrated landscape approaches to building resilience and multifunctionality in the Kailash Sacred

Climate warming-induced rangeland degradation in arid and semiarid steppe imposes substantial threats to the livelihoods of people.But this dilemma can be solved by combining all sectors of agriculture,animal husbandry and tourism through their complement

期刊

Kailash Sacred LandscapeSocio-ecological systemEcosystem-based adaptationInte

Impact of forcing data and land surface properties on snow simulation in a regional climate model:a

Snow is a key variable that influences hydrological and climatic cycles.Land surface models employing snow physics-modules can simulate the snow accumulation and ablation processes.However,there are still uncertainties in modeling snow resources over comp

期刊

WRF/Noah-MP modelInitial and lateral boundary conditionsLand surface propertie