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目的分析狼疮肾炎(LN)患者的免疫功能指标。方法选取65例SLE患者,其中35例并发肾炎为LN组,30例未并发肾炎为SLE无肾炎组,以30例体检健康者作为对照组,同时检测各组外周血T淋巴细胞亚群水平及相关血清学免疫指标。结果 LN患者组外周血CD4+细胞水平、CD4+/CD8+比值及C3水平明显低于SLE无肾炎组及健康人对照组(P<0.05),IgG、IgM、24 h尿蛋白定量、半胱氨酸蛋白酶抑制剂C(CysC)水平明显高于SLE无肾炎组及健康人对照组。结论 LN患者T淋巴细胞亚群数量及补体水平均显著降低,与肾功能损害相关。
Objective To analyze the immune function of patients with lupus nephritis (LN). Methods Sixty-five patients with SLE were enrolled in this study. Thirty-five patients with nephritis were enrolled as LN group, 30 patients without nephritis as nephritis group and 30 healthy people as control group. T lymphocyte subgroups Related serological immune indicators. Results The level of CD4 + cells, the ratio of CD4 + / CD8 + and the level of C3 in peripheral blood of patients with LN were significantly lower than those without nephropathy and healthy controls (P <0.05), while the contents of IgG, IgM, 24 h urine protein and caspase Inhibitor C (CysC) levels were significantly higher than those without SLE nephritis and healthy controls. Conclusions The number of T lymphocyte subsets and the level of complement in LN patients were significantly lower than those in patients with renal dysfunction.