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急性链球菌感染后肾小球肾炎(APSGN)是一种由免疫复合物介导的疾病。但免疫复合物究竟是先在循环中形成然后沉积在肾小球还是在肾小球原位形成则仍待解决。为了进一步评价循环中免疫复合物(CIC)在 APSGN 发病机理中的作用,作者对61例APSGN 患者和13例 A 族链球菌感染的脓疱病病人分别用 C_1q 法和胶固素固相 ELISA(K)法测定 CIC水平,并以20名正常人作对照。61例 APSGN 病人,男40例,女21例,年龄2～74岁,所有病人肾炎发病前均有链球菌感染病史,抗“O”升高。自感染至 CIC 检测时间为9～66天,自肾炎发病至检测时间为1～22天,平均7天。13例脓疱病人从皮肤溃疡处均分离出 A 族链球菌,但无蛋白尿及血尿,血清 C_3正常。20名对照者均为健康医学生。CIC 测定:无论是用固相 C_1q 测定法还是用固
Glomerulonephritis (APSGN) after acute streptococcal infection is a disease mediated by immune complexes. However, whether the immune complexes first formed in the circulation and then deposited in the glomeruli or glomerular in situ formation remains to be resolved. In order to further evaluate the role of circulating immune complexes (CICs) in the pathogenesis of APSGN, 61 patients with APSGN and 13 patients with group A streptococcal impetigo were treated with C_1q method and colloidal solid-phase ELISA K) method for the determination of CIC levels, and 20 normal controls. 61 cases of APSGN patients, 40 males and 21 females, aged 2 to 74 years, all patients had a history of streptococcal infection before onset of nephritis, anti-“O” increased. Since the infection to CIC detection time is 9 to 66 days, since the onset of nephritis to test time was 1 to 22 days, an average of 7 days. 13 cases of pustular patients were isolated from the skin ulcer at Group A streptococci, but no proteinuria and hematuria, serum C_3 normal. Twenty control subjects were all healthy medical students. CIC determination: whether using solid phase C_1q assay or solid