微核测定法作为诊断早期辐射损伤的敏感指标已有不少报道。也有作者用此法作为筛选致癌、致突变和抗放药物的一个快速、简便、可靠的方法。Countryman等发现,以X线照射人外周血淋巴细胞培养物后,淋巴细胞微核增加,并与照射剂量呈线性相关,提示了微核测定法有可能对人类受照剂量作出估计。 Micronuclear assay as a sensitive indicator of early diagnosis of radiation damage has been reported. This method is also used by the authors as a quick, easy and reliable method of screening for carcinogens, mutagens and anti-lethal drugs. Countryman et al. Found that micronuclei of lymphocytes increased after X-ray irradiation of human peripheral blood lymphocyte cultures and correlated linearly with irradiation dose, suggesting that it is possible for the micronucleus assay to estimate human doses.