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笔者发现并验证补体介导炎症损伤的机制是补体活化激活中性粒细胞（ PMN）呼吸爆发所释放的活性氧自由基（ ROS）能再次活化补体，在补体- PMN- ROS之间形成的这一相互反馈活化、增强炎症应答的辅助机制有其特殊的参与调节炎症应答的作用，即补体活化的抑制或 ROS的清除皆能阻滞此活化反馈机制而下调炎症应答。为验证此设想，笔者选择补体活化抑制剂亚硒酸钠（ SS）、抗氧化剂维生素 E（ VitE）与甘草类黄酮（ GF）抑制补体- PMN- ROS活化反馈机制，在试管实验中利用化学发光技术，在 PMN及补体混合培养液中以佛波酯（ TPA）或菊糖单独活化 PMN或补体后检测活性氧的产生量及补体的活化程度；并在小鼠体内实验中观察肺、肝及皮肤血管炎模型的发生率。结果证实此活化反馈上调炎症应答机制的存在；补体活化的抑制或 ROS的清除皆能抑制上调炎症应答，防止血管炎的发生，其发生率可从不服药组的 100％降至各剂量服药组的 20％～ 57％。本研究不但为阐明炎症反应的发生和调控机制提供了新的证据，而且进一步提示 PMN呼吸爆发产生 ROS是炎症反应组织损伤的生理及病理过程中的关键，因此有可能使用营养素抗氧化剂（ nutrient antioxidants）来调节生物炎症反应。以往在一次流行性出血热疫区选择 80例患者仅以亚?
The mechanism by which complement-mediated inflammation is found and validated by reactive oxygen species (ROS) released by the respiratory burst of complement activation-activated neutrophils (PMNs) can reactivate complement, which forms between complement-PMN-ROS A co-mechanism of mutual feedback activation and enhancement of inflammatory response has its special role in regulating the inflammatory response. That is, inhibition of complement activation or ROS clearance can block this activation feedback mechanism and down-regulate the inflammatory response. To validate this hypothesis, the authors selected the inhibitors of complement activation, sodium selenite (SS), antioxidant VitE and glycyrrhizin flavonoids (GF), to inhibit complement-PMN-ROS activation feedback mechanism. In vitro experiments using chemiluminescence Technology, PMN and complement mixed culture medium with phorbol ester (TPA) or inulin activated PMN alone or complement after the detection of reactive oxygen species production and complement activation; and observed in vivo experiments in mice lung, liver and The incidence of cutaneous vasculitis model. The results confirmed that this activation feedback up-regulated the existence of inflammatory response mechanisms; inhibition of complement activation or ROS clearance can inhibit the upregulation of inflammatory responses to prevent the occurrence of vasculitis, the incidence of non-medication group decreased from 100% to each dose group Of the 20% ~ 57%. This study not only provides new evidence for clarifying the mechanism of inflammatory response and regulation, but also further suggests that ROS production from PMN is the key to the physiological and pathological process of inflammatory tissue damage. Therefore, it is possible to use nutrient antioxidants ) To regulate biological inflammation. In the past in an epidemic of hemorrhagic fever epidemic area to select 80 patients only Asia?