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To investigate the relationship between abnormal uterus bleeding and endometrium vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) as well as transforming growth factor β 1 (TGF β 1) expressions among Norplant users. Materials & Methods Thirty six endometrium samples from Norplant users with normal and abnormal bleeding were studied morphologically and immunohistochemically for VEGF, bFGF and TGF β 1 expression. Six normal samples of proliferate endometria were studied as control. Results In the Norplant users, the characteristics of endometrium changed and glands decreased in numbers. The VEGF expression in epithelium and vascular endothelium was lower in those with abnormal uterine bleeding. However, no difference was detected on bFGF and TGF β 1 expression. Conclusion The decline of VEGF expression may relate to the abnormal uterine bleeding in Norplant users.
To investigate the relationship between abnormal uterus bleeding and endometrium vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) as well as transforming growth factor β 1 (TGF β 1) expressions Among Norplant users. Materials & Methods Thirty six endometrium samples Results from the Norplant users, the characteristics of endometrium changed and glands decreased in numbers The VEGF expression in epithelium and vascular endothelium was lower in those with abnormal uterine bleeding. However, no difference was detected on bFGF and TGF β 1 expression. Conclusion The decline of VEGF expression may relate to the abnormal uterine bleeding in Norplant users.