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慢性活动性肝炎(CAH)的组织学特征是肝汇管区及其周围有园形细胞浸润;小叶周围肝细胞呈碎片状坏死;近年,关于CAH发病与肝特异性膜脂蛋白(LSP)诱发的自身免疫反应的关系已有很多研究。本文复习1979年以来关于CAH病因发病学方面的文献,介绍以下问题的近年研究进展:1.CAH的自身抗原与抗体;2.CAP肝细胞损伤机制;3.CAH时的免疫调节功能;4.CAH的病因。
The histological features of chronic active hepatitis (CAH) are the infiltration of park-shaped cells in and around the hepatic portal area; the fragmented necrosis of hepatocytes around the leaflets; and in recent years, the pathogenesis of CAH is associated with liver-specific membrane lipoprotein (LSP) There has been much research on the relationship between autoimmune reactions. This article reviews the literature on causal etiology of CAH since 1979, and presents recent progress in the following issues: 1. Autoantigens and antibodies of CAH; 2. Mechanisms of injury of CAP hepatocytes; 3. Immunoregulatory function at CAH; The etiology of CAH.