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环孢素 A(简称 CyA)是从二种霉菌代谢产物中提取的11个氨基酸组成的多肽。1976等 Jean,Borel 发现它是一种有效的免疫抑制剂,证实其能延长移植物存活时间,并在1978年首次用于治疗骨髓移植患者的移植物对宿主反应(GVH)和同种肾移植,取得了令人满意的疗效。此后,CyA 被广泛应用于人类骨髓,肾、肝、胰腺和心脏移植,有效地减少了排斥反应的发生,延长了移植物的生存率。以下就 CyA 在临床应用中的有关问题作一简述。
Cyclosporin A (referred to as CyA) is extracted from the two kinds of fungal metabolites 11 amino acids of the polypeptide. 1976 et al Jean, Borel found that it is a potent immunosuppressive agent, confirmed that it can prolong graft survival time, and for the first time in 1978 for the treatment of bone marrow transplant patients with graft-versus-host reaction (GVH) and allograft , Has achieved satisfactory results. Since then, CyA has been widely used in human bone marrow, kidney, liver, pancreas and heart transplantation, effectively reducing the incidence of rejection and prolonging the survival of the graft. The following CyA in clinical application of a brief description of the issues.