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目的探讨冷冻胚胎复苏后胚胎继续发育情况与临床妊娠率、种植率、流产率和多胎率的关系。方法采用玻璃化方法冷冻保存第三天胚胎,胚胎复苏后继续培养1d,根据胚胎继续发育情况分为两组:第一组,至少有一个胚胎发育到致密期;第二组,没有胚胎发育到致密期。结果共分析了2011年1月到2012年5月213例复苏移植周期,第一组117个周期,平均移植胚胎2.71枚,临床妊娠率54.70%,种植率28.08%,流产率14.06%,多胎率32.81%。第二组96个周期,平均移植胚胎2.66枚,临床妊娠率40.63%,种植率17.25%,流产率30.77%,多胎率12.82%。两组种植率、流产率和多胎率比较,P<0.05,均具有统计学差异。结论冷冻胚胎复苏后继续发育情况是胚胎质量的重要指标,与临床结局有密切关系。
Objective To investigate the relationship between the development of frozen embryos and clinical pregnancy rate, implantation rate, abortion rate and multiple birth rate after resuscitation. Methods The third day embryos were cryopreserved by vitrification. The embryos were maintained for 1 day after resuscitation. The embryos were divided into two groups according to their continued development. In the first group, at least one embryo developed to a dense phase. In the second group, Dense period. Results From January 2011 to May 2012, 213 cases of resuscitation and transplantation were analyzed. The first group received 117 cycles and the average number of embryos transferred was 2.71. The clinical pregnancy rate was 54.70%, the implantation rate was 28.08%, the abortion rate was 14.06%, the multiple birth rate 32.81%. The second group of 96 cycles, with an average of 2.66 embryos transferred, the clinical pregnancy rate was 40.63%, the planting rate of 17.25%, the abortion rate of 30.77%, the rate of 12.82% multiple births. Two groups of planting rate, abortion rate and multiple birth rate comparison, P <0.05, with statistical differences. Conclusion The development of frozen embryos after resuscitation is an important indicator of embryo quality and is closely related to clinical outcome.