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1978年Forrest等报道去甲基金霉素治疗慢性抗利尿激素分泌不当综合征(SIADH)的效果优于锂。其研究的10个病例,尽管严格限制水份,但平均血钠浓度仍为122±4mmol/L;当服用600—1200mg去甲基金霉素5—14天后,虽不限制水的摄入而血钠浓度却上升到139±1mmol/L。其中有3例用锂治疗无效,但有2例发生可逆性中枢神经系统副作用。自Forrest等的报道以来,对慢性SIADH如限制水份无效,则可采用去甲金霉素治疗。此外,其他
Forrest et al. Reported in 1978 that desmethylplatinomycin was superior to lithium in treating chronic inappropriate secretion of antidiuretic hormone syndrome (SIADH). In its 10 cases of study, the mean serum sodium concentration was 122 ± 4 mmol / L, despite strict water restriction; while taking 600-1200 mg of desmethylcultivirus for 5 to 14 days did not limit water intake and blood Sodium concentration rose to 139 ± 1 mmol / L. Three of them were ineffective with lithium, but two had reversible central nervous system side effects. Since the report by Forrest et al., Naringcillin treatment may be used for chronic SIADH such as limiting moisture. In addition, others