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目的:探讨左氧氟沙星注射液所致不良反应的特点,促进临床合理用药。方法:采用回顾性研究方法,对2003年1月—2011年12月我中心收到省内各ADR监测点上报的175份左氧氟沙星注射液不良反应病例报告进行综合性分析。结果:左氧氟沙星注射液不良反应临床主要表现为皮疹、恶心、呕吐等过敏反应,2例发生过敏性休克;其不良反应发生快,多发生在输液过程中;(18～44)岁年龄段发生率相对较高;累及系统-器官以皮肤及其附件损害最为常见。结论:应加强对我省左氧氟沙星注射液不良反应监测,提高临床合理用药意识,确保患者用药安全有效。
Objective: To investigate the characteristics of adverse reactions caused by levofloxacin injection and to promote rational drug use in clinic. Methods: A retrospective study was carried out to analyze the adverse reactions of 175 cases of levofloxacin injection reported by ADR monitoring stations from January 2003 to December 2011 in our province. Results: Adverse reactions of levofloxacin injection were mainly allergic reactions such as rash, nausea and vomiting, and anaphylactic shock in 2 patients. Adverse reactions occurred more frequently in the infusion process. The incidence of (18-44) years Relatively high; involving the system - organ damage to the skin and its attachments is the most common. Conclusion: It is necessary to strengthen the monitoring of adverse reactions of levofloxacin injection in our province, raise awareness of clinical rational drug use, and ensure the safe and effective use of drugs in patients.