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目的:探讨乳腺癌患者腋窝淋巴结转移的相关因素。方法:回顾性分析675例乳腺癌患者的病理资料,探讨雌激素受体、孕激素受体、人表皮生长因子受体表达规律并分析其与腋窝淋巴结转移的关系。结果:腋窝淋巴结阳性率43.72%,雌激素受体、孕激素受体、Ki-67蛋白阳性率分别为67.16%,71.12%,91.75%,人表皮生长因子受体过表达率14.19%。雌激素受体、孕激素受体、Ki-67蛋白、人表皮生长因子受体与淋巴结转移无相关性。结论:淋巴结转移与雌激素受体、孕激素受体、Ki-67蛋白、人表皮生长因子受体表达是相对独立、相互补充的乳腺癌预后因素。
Objective: To investigate the related factors of axillary lymph node metastasis in breast cancer patients. Methods: The pathological data of 675 breast cancer patients were retrospectively analyzed. The expressions of estrogen receptor, progesterone receptor and human epidermal growth factor receptor (EGFR) were explored and their relationship with axillary lymph node metastasis was analyzed. Results: The positive rate of axillary lymph nodes was 43.72%. The positive rates of estrogen receptor, progesterone receptor and Ki-67 protein were 67.16%, 71.12% and 91.75% respectively. The overexpression rate of human epidermal growth factor receptor was 14.19%. Estrogen receptor, progesterone receptor, Ki-67 protein and human epidermal growth factor receptor have no correlation with lymph node metastasis. CONCLUSION: Lymph node metastasis is associated with the expression of estrogen receptor, progesterone receptor, Ki-67 protein and human epidermal growth factor receptor, which are independent prognostic factors for breast cancer.