ＨＣＶ高变区１ｈｙｐｅｒｖａｒｉａｂｌｅｒｅｇｉｏｎｏｎｅＨＶＲ１基因变异可能与病毒逃避宿主免疫选择作用有关，是病毒在体内持续存在及ＨＣＶ感染易慢性化的重要原因之一１。近年来研究发现，ＨＶＲ１基因可能对ＨＣＶ的免疫预防有重要作用２，３。为此，我们选择了长 Variation in HCV hypervariable region 1hypervariableregiononeHVR1 may be related to the evasion of host immune selection by viruses and is one of the important reasons why the virus persists in vivo and HCV infection is easily chronic1. In recent years, the study found that HVR1 gene may play an important role in HCV immune prevention 2,3. For this reason, we have chosen long