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光动力疗法(PDT)是治疗肿瘤和非肿瘤性疾病的一种新疗法。研究表明PDT可诱导肿瘤局部微环境变化使其更适于抗肿瘤免疫效应的形成;同时PDT可诱导多种免疫细胞快速浸润至肿瘤局部、活化补体系统以及促使多种细胞因子/化学因子的产生和释放,最终启动机体适应性免疫应答。利用PDT还可以制备肿瘤疫苗。近期基础实验证实PDT与免疫疗法联合可提高其抗肿瘤效果。
Photodynamic therapy (PDT) is a new treatment for both oncological and non-neoplastic diseases. Studies have shown that PDT can induce changes in the local tumor microenvironment make it more suitable for the formation of anti-tumor immune effect; the same time, PDT can induce a variety of immune cells quickly infiltrated into the tumor local activation of the complement system and to promote the generation of a variety of cytokines / chemokines And release, eventually start the body adaptive immune response. Tumor vaccines can also be prepared using PDT. Recent basic experiments confirmed that PDT combined with immunotherapy can improve its anti-tumor effect.