目的探讨体重变化对2型糖尿病发病的影响。方法选取2006~2011年连续在某院体检中心体检并排除基线患有恶性肿瘤、冠心病、糖尿病史及空腹血糖(fasting plasma glucose,FPG)≥5.6 mmol/L人群,比较5年中不同体重变化下FPG变化率,运用Logistic回归模型分析研究体重变化与FPG变化的关系。结果随着基线体重的增加,随访过程中FPG变化越明显,偏瘦组(13.48%)、正常组(29.67%)、超重组(48.92%)、肥胖组(57.18%)各组间比较FPG变化差异均有统计学意义;在随访过程中体重未控制组FPG变化(49.18%)高于体重保持正常或控制组(29.46%);与随访过程中体重保持正常相比,保持肥胖组有可能发展成糖尿病的危险性最大RR为2.953,95%CI为2.288~3.811,其次为超重转为肥胖组,RR为2.267,95%CI为1.155~3.305,而肥胖转为超重组RR为1.673,95%CI为1.051~2.661危险性要小于保持超重组RR为1.899,95%CI为1.194~2.262及超重转为肥胖组,正常转为超重组RR为1.537,95%CI为1.155~2.046危险性亦高于体重保持正常组。结论有效的体重控制可以降低糖尿病的发病风险。 Objective To investigate the impact of body weight changes on the incidence of type 2 diabetes mellitus. Methods From 2006 to 2011, we continuously performed physical examination in a hospital physical examination center and excluded the patients with baseline malignant tumor, coronary heart disease, diabetes mellitus and fasting plasma glucose (FPG) ≥ 5.6 mmol / L from baseline, Under the FPG rate of change, the use of Logistic regression model analysis of changes in body weight and FPG changes. Results With the increase of baseline body weight, the changes of FPG were more obvious during the follow-up period. Compared with the control group, the change of FPG in the group of overweight (13.48%), normal group (29.67%), overweight group (48.92%) and obesity group (49.18%) were higher than normal weight control group (29.46%) during the follow-up period. Compared with the normal body weight during follow-up, it is possible to maintain the obesity group The risk of diabetes mellitus was 2.953, 95% CI was 2.288-3.811, followed by overweight to obesity group, RR was 2.267, 95% CI was 1.155-3.305, and obesity was overweight group RR was 1.673, 95% The CI of 1.051-2.661 was less than the risk of maintaining overweight group was 1.899,95% CI 1.194-2.262 and overweight to obesity group, normal to overweight group RR was 1.537, 95% CI was 1.155 ~ 2.046 risk is also high Maintain normal weight in weight group. Conclusion Effective weight control can reduce the risk of diabetes.