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目的探讨外周血T淋巴细胞共刺激分子,程序性细胞死亡因子-1(PD-1)和CD28在急性冠脉综合征(ACS)疾病进展中的意义。方法选取急性心肌梗死(AMI组)患者25例、不稳定型心绞痛(UAP组)患者25例、稳定型心绞痛(SAP组)患者10例作为研究对象,临床上冠脉造影正常的患者11例作为对照组,采用流式细胞仪测定各组患者CD4+T淋巴细胞上PD-1和CD28的表达情况。结果与SAP组和对照组相比,AMI组及UAP组CD4+、PD-1+双阳性细胞比例增高(P<0.05),而CD4+、CD28+双阳性细胞比例无明显变化(P>0.05)。结论急性冠脉综合征患者中,作为负调控因子的PD-1表达增强,可能在冠状动脉粥样硬化斑块失稳定和疾病进展中起到作用。
Objective To investigate the significance of peripheral blood T lymphocyte costimulatory molecules, programmed cell death factor-1 (PD-1) and CD28 in the progression of acute coronary syndrome (ACS). Methods Twenty-five patients with acute myocardial infarction (AMI), 25 patients with unstable angina (UAP) and 10 patients with stable angina (SAP) were enrolled in this study. Eleven patients with normal coronary angiography In the control group, the expression of PD-1 and CD28 on CD4 + T lymphocytes in each group was determined by flow cytometry. Results Compared with SAP group and control group, the proportion of CD4 +, PD-1 + double positive cells in AMI group and UAP group increased (P <0.05), while there was no significant change in the proportion of CD4 + and CD28 + double positive cells (P> 0.05). Conclusion The expression of PD-1, as a negative regulator, is increased in patients with acute coronary syndromes and may play a role in the destabilization of coronary atherosclerotic plaque and disease progression.