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幽门螺杆菌(H.pylori)感染造成的炎症反应,可刺激诱导型NO合酶(inducible NO synthase,iNOS)产生大量的NO,对胃癌的启动和发展起重要作用。进入20世纪90年代以来,一氧化氮(NO)研究跨入了迅猛发展的阶段,许多调节功能及其在病理生理过程中所起的重要作用被逐渐认识,特别是NO在致癌和致突变过程中表现的双重性,更是近年的研究热点之一。本文就NO、iNOS与胃癌关系的研究进展作一综述。 1 NO的生物学作用 内源性NO由NOS催化左旋-精氨酸(L-Arg)末端胍基中一个氮原子氧化而生成。NO是一种活性很强的无机自由基气体,带有不成对电子,其化学性质极不稳定,体内T_(1/2)仅3s～5s,难以直接测定,NO呈脂溶性,容易通过生物膜,具有氧化
The inflammatory response caused by H. pylori infection stimulates inducible NO synthase (iNOS) production of large amounts of NO, which plays an important role in the initiation and development of gastric cancer. Since the 1990s, research on nitric oxide (NO) has entered a stage of rapid development. Many regulatory functions and their important role in pathophysiological processes have been gradually recognized, especially NO in carcinogenesis and mutagenesis. The duality of performance is one of the research hotspots in recent years. This article reviews the research progress of the relationship between NO, iNOS and gastric cancer. 1 Biological Action of NO Endogenous NO is produced by the oxidation of a nitrogen atom in the terminal sulfhydryl group catalysed by NOS catalyzed by L-arginine (L-Arg). NO is a highly reactive inorganic radical gas with unpaired electrons. Its chemical properties are extremely unstable. In vivo T_(1/2) is only 3s~5s. It is difficult to measure directly. NO is fat-soluble and easy to pass through. Film with oxidation