论文部分内容阅读
目的:探讨输精管结扎术对男性中老年期血清雄激素水平的远期影响。方法:采用分层整群抽样的方法,抽取遵义地区40岁及以上成年男性437例(有输精管结扎史232例,无结扎史205例)进行问卷调查、体格检查,并检测其血清总睾酮(TT)、性激素结合球蛋白(SHBG)和黄体生成素(LH),计算游离睾酮(c FT)、睾酮分泌指数(TSI)、游离睾酮指数(FTI)。结果:结扎组TT(17.39±6.57)nmol/L、SHBG(70.28±40.90)nmol/L和LH(10.85±11.73)IU/L均显著高于非结扎组的(16.01±5.41)nmol/L、(58.91±36.89)nmol/L和(8.86±6.49)IU/L,P均<0.05;结扎组FTI(0.30±0.12)显著低于非结扎组(0.33±0.15),P<0.05;结扎组c FT(0.23±0.09)nmol/L、TSI(2.46±1.51)nmol/IU与非结扎组(0.24±0.07)nmol/L、(2.42±1.34)nmol/IU相比,差异无统计学意义(P均>0.05)。校正相关因素后,结扎组与非结扎组相比,TT(β:1.015,95%CI:-0.180,2.210)、SHBG(β:5.118,95%CI:-2.069,12.305)、c FT(β:0.003,95%CI:-0.011,0.018)、FTI(β:-0.012,95%CI:-0.035,0.011)、TSI(β:0.138,95%CI:-0.131,0.407)、LH(β:1.011,95%CI:-0.811,2.834)差异均无统计学意义(P均>0.05)。结论:输精管结扎术对男性中老年期血清雄激素水平未见明显的远期影响。
Objective: To investigate the long-term effect of vasectomy on serum androgen levels in middle-aged men. Methods: Stratified cluster sampling method was used to survey 437 cases (232 cases with vasectomy and 205 cases without ligation) of adults aged 40 years and older in Zunyi district for questionnaire, physical examination and total serum testosterone TT, SHBG and LH were calculated. Free testosterone (c FT), testosterone secretion index (TSI) and free testosterone index (FTI) were calculated. Results: Compared with non-ligation group (16.01 ± 5.41) nmol / L, the ligation group had significantly higher TT (17.39 ± 6.57) nmol / L, SHBG (70.28 ± 40.90) nmol / L and LH (10.85 ± 11.73) (58.91 ± 36.89) nmol / L and (8.86 ± 6.49) IU / L respectively, P <0.05; FTI in ligation group was significantly lower than that in non-ligation group (0.33 ± 0.15, P <0.05) Compared with non-ligated group (0.24 ± 0.07) nmol / L and (2.42 ± 1.34) nmol / IU, there was no significant difference between the two groups (P 0.23 ± 0.09 nmol / L, T 2.46 ± 1.51 nmol / All> 0.05). After adjusting for related factors, TT (β: 1.015, 95% CI: -0.180, 2.210), SHBG (β: 5.118, 95% CI: -2.069, : 0.003, 95% CI: -0.011,0.018), FTI (β: -0.012, 95% CI: -0.035,0.011), TSI (β: 0.138, 95% CI: -0.131,0.407), LH 1.011, 95% CI: -0.811, 2.834). There was no significant difference (all P> 0.05). Conclusion: Vasectomy has no obvious long-term effect on serum androgen levels in middle-aged and elderly men.