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可乐定(Clo,1 mg/kg,ip)能显著抑制小鼠烫伤后血浆游离血红蛋白含量的增加,此作用可被育亨宾(5 mg/kg,ip)阻断而不受哌唑嗪(10 mg/kg,ip)的影响(P<0.01)。作者发现Clo能显著降低小鼠烫伤后红细胞的渗透脆性。50％溶血的盐水浓度:ClO组为 5.77±0.26 g/L。而生理盐水对照组(NS)为 6.57±0.21g/L(P<0.01)。预处理小鼠烫伤后,全血超氧化物歧化酶(SOD)的活性显著降低(P<0.01),并能抑制全血的超微弱发光强度60 s的积分值:Clo组为377.8±155.2;NS组为824.6±245.6,P<0.01;峰值:Clo组为 69.2±23.5 min;NS组 102.4±9.6 min,均P<0.01)。提示Clo可降低细胞内氧自由基的产生,从而减少脂质过氧化反应的程度,并降低小鼠烫伤后全血SOD的活性。
Clonidine (Clo, 1 mg/kg, ip) significantly inhibited the increase of plasma free hemoglobin after scald in mice, and this effect was blocked by yohimbine (5 mg/kg, ip) but not by prazosin ( Effect of 10 mg/kg, ip) (P<0.01). The authors found that Clo can significantly reduce erythrocyte osmotic fragility after scald in mice. The 50% hemolyzed saline concentration was 5.77±0.26 g/L in the ClO group. The saline control group (NS) was 6.57±0.21 g/L (P<0.01). After the scald of the pretreated mice, the activity of superoxide dismutase (SOD) in the whole blood was significantly reduced (P<0.01), and the integrated value of the superweak luminescence intensity of whole blood was suppressed for 60 s: the Clo group was 377.8±155.2; The NS group was 824.6±245.6, P<0.01; the peak value was 69.2±23.5 min in the Clo group and 102.4±9.6 min in the NS group (P<0.01). It is suggested that Clo can reduce the production of oxygen free radicals in cells, thereby reducing the degree of lipid peroxidation and reducing the activity of SOD in whole blood after scald in mice.