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细胞表面跨膜糖蛋白CD44，具有多种结构形式，肿瘤发生早期有CD44变异体的表达，CD44v表达与肿瘤转移有关。本文综述了自1992年第一份临床肿瘤标本CD44检测后，胃肠道肿瘤中CD44表达的研究情况。
The transmembrane glycoprotein CD44 on the cell surface has a variety of structural forms. There are CD44 variants in the early stage of tumorigenesis. The expression of CD44v is related to tumor metastasis. This article reviews the status of CD44 expression in gastrointestinal tumors since the first clinical tumor specimen CD44 was tested in 1992.