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自 Palmer 等报告新近起病、未用胰岛素治疗之I 型糖尿病患者,血清抗胰岛素自身抗体(IAA)检出率甚高以后,尚发现该型患者的非糖尿病近亲者该抗体也呈高检出率,故有可能将此抗体视为Ⅰ型糖尿病的预测指标。本文作者对日本人未经胰岛素治疗的Ⅰ型糖尿病患者之近亲者检测 IAA,并观察其与组织相容性抗原(HLA)、胰岛细胞膜抗体(ICSA)及糖耐量(OGTT)的关系.10例Ⅰ型糖尿病患者的近亲20名,年龄15～50岁,病程3月～34年。近亲中双亲10名(父4名,母6名)、同胞6名(男4名,女2名),子女4名(男
Since Palmer et al reported recently onset of insulin-independent type 1 diabetes in patients with very high detection rates of serum anti-insulin autoantibodies (IAA), they were also found to be highly detectable in non-diabetic relatives of this type Rate, it is possible that this antibody as a predictor of type I diabetes mellitus. In this study, we detected IAA in close relatives of non-insulin-treated type 1 diabetic patients and observed their association with HLA, ICSA and OGTT. Type 20 diabetes, the close relatives 20, aged 15 to 50 years old, duration of 3 months to 34 years. Relatives in the parent 10 (4 father, 6 mother), siblings 6 (4 males, 2 females), children 4 (male