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目的 :探讨胃粘膜癌前病变与胃癌之间的关系。方法 :应用免疫组化SP法检测异型增生、肠上皮化生和萎缩性胃炎等胃癌前病变组织中细胞增殖核抗原 (PCNA)、表皮生长因子 (EGFR)、凋亡抑制基因 2 (bcl 2 )的表达 ,并与胃癌及正常胃组织进行对照比较。结果 :胃癌与异型增生比较 ,PCNA、EGFR、bcl 2的表达均无显著性差异 (P均 >0 .0 5 ) ;与肠上皮化生和萎缩性胃炎比较 ,PCNA、EGFR的表达有高度显著性差异 (P均 <0 .0 1) ,bcl 2的表达有显著性差异 (P <0 .0 5 ) ;与正常胃粘膜比较 ,PCNA、EGFR、bcl 2的表达均有高度显著性差异 (P均 <0 .0 1)。结论 :PCNA、EGFR、bcl 2的表达在胃粘膜的恶性转化过程中起着重要作用 ,联合检测这些指标有助于癌前病变和早期胃癌的诊断。
Objective: To investigate the relationship between gastric mucosal precancerous lesions and gastric cancer. Methods: Immunohistochemical SP method was used to detect the expression of proliferating cell nuclear antigen (PCNA), epidermal growth factor (EGFR) and apoptosis inhibitor 2 (bcl 2) in gastric precancerous lesions such as dysplasia, intestinal metaplasia and atrophic gastritis. And compared with gastric cancer and normal gastric tissue. Results: There was no significant difference in the expression of PCNA, EGFR and bcl2 between gastric cancer and dysplasia (all P> 0.05). Compared with intestinal metaplasia and atrophic gastritis, the expression of PCNA and EGFR was significantly higher There were significant differences in the expression of bcl 2 between the two groups (P <0.05) (P <0.05). Compared with normal gastric mucosa, the expressions of PCNA, EGFR and bcl 2 were highly significant P <0.01). Conclusion: The expression of PCNA, EGFR and bcl2 plays an important role in the malignant transformation of gastric mucosa. The combined detection of these indexes is helpful for the diagnosis of precancerous lesions and early gastric cancer.